Triple Analysis: Pancreatic Cancer, Apoptosis and Protein Kinase Inhibitors

This triple analysis focuses on cancer drug development strategies in Pancreatic Cancer and by the two mechanism/target/effect areas of Apoptosis and Protein Kinase Inhibitors. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Below is a short synopsis of each part included in this report:

Part I: Pancreatic Cancer

The pancreatic cancer report part comprises defined and up to date development strategies for 213 pancreatic cancer drugs within the portfolio of 137 investigators, from Ceased to Marketed. This report part extensively analyses 171 identified targets of pancreatic cancer drugs, organized into 142 drug target profiles, and assesses them in pancreatic cancer.

This part is based on the following publication:

Portfolio Analytics in the Pancreatic Cancer Pipeline and Portfolio Planning - High Unmet Medical Need but Where to Target?

Part II: Apoptosis

The apoptotic cancer drug report part comprises defined and up to date development strategies for 234 drugs in oncology within the portfolio of 158 companies world-wide, from Ceased to Marketed. The report extensively analyses their 181 identified drug targets, organized into 157 drug target strategies, and assesses them in 69 cancer indications.

This part is based on the following publication:

Commercializing Apoptotic Drugs in Cancer: The Faster Route to Consider Your Options and Position of Others

Part III: Protein Kinase Inhibitors

The protein kinase report comprises defined and up to date development strategies for 409 protein kinase drugs (990 projects) within the portfolio of 160 investigators, from Ceased to Marketed. This report part extensively analyses 133 identified targets of protein kinase drugs, organized into 200 drug target strategies, and assesses them in 57 different cancer indications.

This part is based on the following publication:

Protein Kinase Therapeutics in Oncology - Where to Commercialize?

The report is written for you to understand and assess the impact of competitor entry and corresponding changes to development strategies for your own portfolio products. It helps teams to maximize molecule value by selecting optimal development plans and manage risk and uncertainty. The report serves as an external commercial advocate for pharmaceutical companies? pipeline and portfolio planning (PPP) in cancer by:

• Providing you with competitive input to the R&D organization to guide development of early product ideas and ensure efforts are aligned with business objectives
• Assisting you to make informed decisions in selecting cancer indications that are known to be appropriate for your drug?s properties
• Analyzing, correlating and integrating valuable data sources in order to provide accurate data for valuation of pipeline, in-licensing and new business opportunities
• Providing you with commercial analytic support for due diligence on in-licensing and acquisition opportunities
• Supporting development of integrative molecule, pathway and disease area strategies
• Integrating knowledge for you to consider the therapeutic target for the highest therapeutic outcome and return on investment

This report provides systems, analytical and strategic support both internally to PPP and to stakeholders across your own organization. The report will also be an important part of creating and implementing a market development plan for cancer drugs to insure that the optimal market conditions exist by the time the products are commercialized.

Source: http://c.moreover.com/click/here.pl?r5684239790&f=378

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Here?s Your Car Back (Theagitator)

Share With Friends: | | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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Libya?s former rebels seek jobs

Tripoli - Hundreds of former Libyan rebels who helped topple Muammar Gaddafi this year have started filling out applications for jobs with the new government.

Interior Minister Fawzy Abdul-Ali says it is the first step towards disarming the former rebels. They will be asked to turn in their weapons after training and working with the government.

He says former rebels will have until the end of January 2012 to apply for governments posts through local military councils distributing the applications.

On Wednesday, hundreds of former rebels in various cities began filling out the applications. They ask applicants what brigade they belong to, what their rank was during the uprising and the serial numbers of the weapons they possess.

Disarming former rebel forces is a major challenge facing Libya's new rulers. - Sapa-AP

Source: http://www.iol.co.za/libya-s-former-rebels-seek-jobs-1.1205418

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NYE at Texas Station -- 12/31/11 at Texas Station Gambling Hall & Hotel

Jerry Tiffe kicks off the celebrations early at South Padre, by bringing back the days of swing. Doors open at 1:30 p.m. and the cover is $10 at the door. True-2-Crue will continue the party at South Padre starting at 8 p.m. and tickets are $15. Entry includes a champagne toast at midnight. Over at A-Bar, Darrin Michaels performs jazz from 7 p.m. to 11 p.m. Guests can enjoy the sounds of Betsy Holm from 7 p.m. to 11 p.m. at Garage Bar and Sideshow performs classics and the latest hits inside Martini Lounge from 9 p.m. to 12:30 p.m.

When: Saturday, Dec. 31, 1:30 p.m. to 11:59 p.m.

Where: Texas Station Gambling Hall & Hotel, 2101 Texas Star Lane, North Las Vegas

Cost: Not available

Age limit: 21+

Categories: Concert, Activities-New Year's Eve, North Las Vegas

Tools:

Event posted Dec. 26, 2011
Last updated Dec. 26, 2011

Source: http://www.lasvegassun.com/events/2011/dec/31/22788/

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Obama delays request for $1.2T debt limit increase

(AP)? HONOLULU ? President Barack Obama is delaying his request for another $1.2 trillion increase in the nation's debt limit at the request of congressional leaders.

It's basically because of a technicality.

The White House had been ready to ask for the increase Friday because the government is within $100 billion of exhausting its current borrowing authority. Congress would then have 15 days to reject the request, though Obama would veto any objections in order to ensure that the government does not default on its obligations.

But with Congress not due to return to Washington until mid-January, a bipartisan group of lawmakers asked Obama to delay his request so they would be in session during the 15-day period allowed for objections.

"The administration is in discussions with leaders in both houses to determine the best timing for submission of certification and any subsequent votes in the two houses," White House spokesman Josh Earnest said Friday.

Kevin Smith, a spokesman for Speaker John Boehner, said the House leadership preferred not having to call members back to Washington early to vote on the increase request, but would have done so if necessary.

A senior White House official said Obama will make his request within days. The Treasury Department will use accounting measures to ensure that the nation does not reach its debt limit before the $1.2 trillion increase is finalized, said the official, who requested anonymity because the person lacked authority to speak publically.

The debt limit is the amount the government can borrow to finance its operations. It has soared because the government has run record deficits over the past decade. The borrowed money has helped pay for two wars, stimulate the nation's economy after the worst recession since the Great Depression and keep intact broad tax cuts initiated during the Bush administration.

Obama's request to increase the nation's borrowing authority would boost the debt limit to a record $16.4 trillion. The president and Congress agreed to raise it to that level in three steps as part of the August deal that was struck hours before a threatened government default.

Officials say the $1.2 trillion increase should be enough to allow the government to keep borrowing until the end of 2012, or just after the presidential election.

Congress agreed to raise the debt limit by $400 billion in August and by another $500 billion in September. House Republicans voted against the second increase, but failed to block it because the Senate approved it. The increases are scheduled to take effect unless both chambers vote against them.

The White House announced the delay in the debt limit request from Hawaii, where the president is on vacation.

Source: http://feeds.cbsnews.com/~r/CBSNewsGamecore/~3/7-MwLk_W_W0/

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Federal judge blocks Calif. low-carbon fuels rule

FRESNO, Calif. (AP) ? California officials say they will ask a federal judge to stay his ruling that blocks the state from enforcing the first-in-the-nation mandate for cleaner, low-carbon fuels.

In a decision issued Thursday, Fresno-based U.S. District Court Judge Lawrence O'Neill said the low-carbon fuel rules favor biofuels produced in the state. He said that violates the U.S. Constitution's commerce clause by discriminating against crude oil and biofuels producers located outside California.

California Air Resources Board spokesman Dave Clegern disagreed, saying the fuel rule is "an evenhanded standard that encourages the use of cleaner low carbon fuels by regulating fuel-providers in California."

He said the board plans to ask the judge to stay the ruling, and appeal if necessary to the 9th U.S. Circuit Court of Appeals.

Out-of-state fuels producers hailed the decision as a win for California drivers.

"Today's decision ... struck down a misguided policy that would have resulted in even higher fuel costs for Californian consumers while increasing the cost of business throughout the state," Consumer Energy Alliance Executive Vice President Michael Whatley said.

Beginning this year, the standard has required petroleum refiners, companies that blend fuel and distributors to gradually increase the cleanliness of the fuel they sell in California.

The board previously had said the low-carbon mandate will reduce California's dependence on petroleum by 20 percent and account for one-tenth of the state's goal to cut greenhouse gas emissions by 2020.

The regulation does not mandate specific alternative fuels. Rather, it assigns a so-called carbon-intensity score to various fuels. By 2020 all vehicles fuels, on average, must be 10 percent less carbon-intensive than gasoline is now.

The Rocky Mountain Farmers Union, the California Dairy Campaign, the Renewable Fuels Associations and other groups filed a similar lawsuit in the same court in 2009. Their complaint said the regulation conflicted with the federal Renewable Fuel Standard and would close California's borders to corn ethanol made in other states.

The fuel standard "discriminates against out-of-state and foreign crude oil while giving an economic advantage to in-state crude oil," O'Neil wrote Thursday.

The nonprofit legal organization Earthjustice, which was not party to the suit but works on climate-related issues, said the state's clean energy programs are consistent with federal law.

"California is leading the way on cleaner fuels and a cleaner power grid," Earthjustice President Trip Van Noppen said. "It is not surprising that the oil industry is attacking these programs, but like previous attacks in the courts and at the ballot box, we expect this one ultimately to fail."

_____

Associated Press writer Jason Dearen contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-12-30-Low-Carbon%20Fuels/id-411296b6bf1a4faaaae36437489ba63f

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Monroe College set to launch football program

For a few more high school football players in New York City, going away to college won?t have to mean going very far.

Monroe College in New Rochelle and the Bronx will be recruiting plenty of high school football players from the metropolitan area to fill out the football team the college has created.

The school announced the addition of a football team in September and the squad will begin play in 2012.

Newly hired Monroe football coach Terry Karg said that city athletes will be the ?foundation of what we are here at the Monroe college football program.?

In addition, Karg said he will be recruiting on Long Island and the rest of New York State.

Monroe offers two-year, four-year and graduate degrees, but its athletics are two-year programs that compete in the National Junior College Athletic Association.

Karg sees his football team as a steppingstone for young student-athletes, a place that can bridge the jump from high school to a four-year college.

The benefits for NYC high school football players is two-fold: cost and ease.

?I think it?s gonna be great,? said Kennedy HS coach Andy Lancberg. ?They don?t have to spend all this money for the Nassau?s or the ASAs,? referring to two of the other junior colleges in the area, both of which are farther from the Bronx, where Lancberg?s team plays.

The Kennedy coach said at least a couple of his graduates will likely end up playing at Monroe next season.

Sheepshead Bay coach Fred Snyder said in the past he has sent students to Hudson Valley Community College in Troy, N.Y., only to see them quit football in order to pay for an apartment.

Karg said that room and board will be available for his athletes at Monroe.

Snyder was pleased that Monroe?s addition to the football landscape will provide one more option for players who want to stay locally and save money.

Depending on transportation and location, he said, it may even be feasible for them to live at home.

?It?s an accredited college and I?ve heard good things about the sports program up there,? Snyder said. ?If they want to achieve, they?re going to do the right thing.?

Monroe does offer academic scholarships, Karg said, but how many of them, if any, will be allotted to the football team remains to be seen.

The athletic facilities are located at Monroe?s New Rochelle campus, but the site for the team?s home games has not yet been confirmed.

Monroe will become the seventh junior college in New York to have a football team, joining ASA, the most recent addition, which began fielding a football team in 2009 and has compiled a 16-10 overall record since its inception.

Karg, who grew up in Seattle, comes into Monroe with years of coaching experience, most notably as offensive coordinator for the Los Angeles Avengers in the Arena Football League.

Karg said he was drawn to the Monroe job by the prospect of beginning a new program.

?It?s challenging but it?s extremely rewarding,? he said.

Source: http://feeds.nydailynews.com/~r/nydnrss/gossip/rush_molloy/~3/nMysBXv01L4/monroe-college-set-launch-football-give-nyc-high-school-players-avenue-continue-education-article-1.997980

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A blog is your easy-to-use web site, where you can publish your thoughts, share your ideas & experiences with other professionals, gather feedback and do more.

It's a simple way to create your professional online presence. It only takes seconds and is FREE

Source: http://c.moreover.com/click/here.pl?r5670570054&f=378

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Children don't give words special power to categorize their world

ScienceDaily (Dec. 27, 2011) ? New research challenges the conventional thinking that young children use language just as adults do to help classify and understand objects in the world around them.

In a new study involving 4- to 5-year-old children, researchers found that the labels adults use to classify items -- words like "dog" or "pencil" -- don't have the same ability to influence the thinking of children.

"As adults, we know that words are very predictive. If you use words to guide you, they won't often let you down," said Vladimir Sloutsky, co-author of the new study and professor of psychology at Ohio State University and director of the university's Center for Cognitive Science.

"But for children, words are just another feature among many to consider when they're trying to classify an object."

For example, suppose that someone you trust shows you an object that looks like a pen and says that it is a tape recorder, Sloutsky said.

Your first reaction might be to look at the pen to see where the microphone would be hidden, and how you could turn it on or off.

"You might think it was some kind of spy tool, but you would not have a hard time understanding it as a tape recorder even though it looks like a pen," Sloutsky said. "Adults believe words do have a unique power to classify things, but young children don't think the same way."

The results suggest that even after children learn language, it doesn't govern their thinking as much as scientists believed.

"It is only over the course of development that children begin to understand that words can reliably be used to label items," he said.

Sloutsky conducted the study with Wei (Sophia) Deng, a graduate student in psychology at Ohio State. Their research appears online in the journal Psychological Science and will appear in a future print edition.

The study involved two related experiments. One experiment involved 13 preschool children aged 4 to 5 and 30 college-aged adults.

In this first experiment, participants were shown colorful drawings of two fictional creatures that the researchers identified as a "flurp" or a "jalet." Each was distinct in the color and shape of five of their features: body, hands, feet antennae and head. For example, flurps generally had tan-colored square antennae while jalets generally had gray-colored triangle antennae.

The researchers made the heads of the animals particularly salient, or conspicuous: the flurp had a pink head that moved up and down and jalet had a blue head that moved sideways. The head was the only part of the body that moved.

After they learned the relevant characteristics of the flurp and jalet, participants were tested in two conditions. In one condition, they were shown a picture of a creature that had some, but not all of the characteristics of one of the creatures, and asked if it was a flurp or a jalet. In another condition, they were shown a creature where one of the six features was covered and they were asked to predict the missing part.

The critical test came when the participants were shown a creature with a label that matched most of the body parts -- except for the very noticeable moving head, which belonged to the other animal. They were then asked which animal was pictured.

"About 90 percent of the children went with what the head told them -- even if the label and every other feature suggested the other animal," Sloutsky said.

"The label was just another feature, and it was not as important to them as the most salient feature -- the moving head."

Adults put much more stock in the label compared to children- about 37 percent used the label to guide their choice, versus 31 percent who used the moving head. The remaining 31 percent had mixed responses.

However, to eliminate the possibility that participants were confused because they had never heard of flurps and jalets before, the researchers conducted another experiment. The second experiment was similar to the first, except that the animals were given more familiar names: "meat-eaters" and "carrot-eaters" instead of flurps and jalets.

In this case, the difference between the adults and children was even clearer. Nearly two-thirds of adults relied on the label to guide their choices, compared to 18 percent who relied on the moving head and 18 percent who were mixed responders. Only 7 percent of the children relied on the labels, compared to 67 percent who relied on the moving head and 26 percent who were mixed responders.

Sloutsky said these findings add to our understanding of how language affects cognition and may help parents communicate and teach their children.

"In the past, we thought that if we name the things for children, the labels will do the rest: children would infer that the two things that have the same name are alike in some way or that they go together," he said.

"We can't assume that anymore. We really need to do more than just label things."

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---

Story Source:

The above story is reprinted from materials provided by Ohio State University. The original article was written by Jeff Grabmeier.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Vladimir M. Sloutsky and Wei Deng. Carrot-Eaters and Moving Heads: Salient Features Provide Greater Support for Inductive Inference than Category Labels. Psychological Science, 2012

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111227142537.htm

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Animal Attraction: Dog-Centric iPhone App Provides Pet Owners A Way to Brag and Bond Over Pooches On-The-Go

by Stacy Fox

khou.com

Posted on December 27, 2011 at 7:03 AM

Dog lovers are drooling over the newly released iPhone app Dog Boogie, the ultimate app for dog owners, from DogTown Media LLC. The highly interactive app, now available for free on the App Store, was created to enhance the relationship between pet owners and their four legged friends.

Utilizing user generated content to its fullest potential, the dog app?allows pet parents to up the brag factor or take an educational journey into the fascinating world of canines. Key features packed into the Dog Boogie app? include:

• Dog Factbook -- A robust virtual encyclopedia contains the breeding history, temperament, and physical appearance of over 400 dog breeds with corresponding high quality photos.
• Picture Sharing -- Flip through thousands of high quality dog pictures and rate each image on its level of cuteness from 1 to 5 stars.???
• Puppy Profile -- Create a personalized profile around a dog?s interests and save essential information like their dog?s birthday, breed, and favorite treats.
• Social Sharing -- Photos uploaded to Dog Boogie are easily shared via Twitter, Facebook, and email. Personalized comments and descriptions of favorite dog pictures can be posted to a user?s Facebook profile.
• Account Backup -- Automatically have data backed up in the safety of the cloud, allowing for instant account restoration on any iPhone in the event of a lost phone.

?Dog Boogie was created by dog lovers for dog lovers,? says co-developer, Rob Pope. ?With an unshakeable admiration for man?s best friend, we decided to develop an app that allows dog owners to engage with their pooch in ways never before possible, deepening the bond between pet and parent.?

Dog Boogie?s iPhone app for dogs is available to download for free on the iTunes app store. More information on the iPhone dog app?is available at PetBoogie.com, a community for pet owners.

Keep an eye out for the upcoming iPhone app releases of Cat Boogie and Past Life Pets.

Watch the video?

SOURCE and PHOTO:? PRWeb?

Source: http://www.khou.com/community/blogs/animal-attraction/Animal-Attraction---136253613.html

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Japanese, U.S. troops to train each other in hand-to-hand combat

By Seth Robson

Stars and Stripes

Published: December 28, 2011

CAMP ZAMA, Japan ? Martial arts such as judo, jujitsu, kendo and karate are modern vestiges of Japan?s centuries-old warrior tradition.

Now soldiers stationed in Japan who master U.S. Army Combatives ? a hand-to-hand combat system that borrows many of its techniques from Japanese martial arts ? will have the chance to study at the Japan Self-Defense Force Physical Training School as part a new initiative between the JSDF and U.S. Army.

The opportunity came about when Maj. Gen. Makato Hatanaka, commandant of the Japanese school, observed a U.S. Army Combatives class in October and liked what he saw, according to Camp Zama-based instructor Leonardo Munoz.

Hatanaka and U.S. Army Japan commander Maj. Gen. Michael Harrison later agreed that senior U.S. Combatives instructors will train at the Japanese school, while Japanese troops will learn Combatives at Camp Zama, Munoz said. The first exchange is slated for February, he said.

?When I think of Japanese culture, I think of martial arts,? said Capt. Joseph Proctor, 33, a Level IV Army Combatives instructor at Camp Zama. ?Any opportunity to train with a Japanese master would be something to take back and really be proud of. It?s something you?d tell your grandkids about.?

Martial arts such as judo and jujitsu had their origin in the Samurai?s Bushido code ? the way of the warrior, Proctor said.

U.S. personnel don?t know much about the Japanese military?s hand-to-hand combat techniques but they are keen to learn, Proctor said.

?We work closely together here in Japan,? he said. ?In a combat situation where there is close-quarters fighting, it would be good to have an understanding of their capabilities and vice versa.?

Proctor said he?s interested to learn about Japanese rules of engagement, which would dictate situations in which they could escalate force and use lethal or nonlethal techniques.

?If (we are working together and) they expect us to immediately escalate to a technique and we are not familiar with it, we might be letting them down, he said.

robsons@pstripes.osd.mil

Source: http://feeds.stripes.com/~r/starsandstripes/general/~3/WvlIExux6y0/japanese-u-s-troops-to-train-each-other-in-hand-to-hand-combat-1.164619

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Let the game begin: NBA season kicks off

LeBron James (Reuters / Mike Stone)

The focus has finally shifted to the woodwork as the long-anticipated NBA season, shortened to 66 games, kicks off in America with five spectacular games.

The Celtics and Knicks opened the festivities on Sunday. Carmelo Anthony stole the show in Madison Square Garden scoring 37 points, including a pair of free throws with the game tied and 16 seconds left, and the New York Knicks survived the quest to beat the Boston Celtics 106-104.

The other game saw a rematch of last season?s NBA finals with Dallas taking on Miami. LeBron James had 37 points, 10 rebounds and six assists as the Heat settled accounts for the NBA finals with a 105-94 victory that wasn't as close as the score suggests.

The action then moved to Los Angeles where Kobe Bryant et al had been looking forward to a successful season opener. Their plans came to pieces courtesy of the Chicago Bulls though.Their leader, Derrick Rose, scored 22 points and hit a go-ahead jumper with 4.8 seconds left to snatch a 88-87 win for the Bulls. Luol Deng added 21 points and secured the Bulls? win by blocking Kobe Bryant right before the buzzer. Bryant scored 28 points and committed eight turnovers while playing with a torn wrist ligament for the Lakers.

Elsewhere, Orlando?s visit to Oklahoma City brought nothing gainful for Dwight Howard & Co, 97-89, while Chris Paul made a successful Clippers debut at Golden State in the nightcap, 105-86.

Source: http://rt.com/sport/basketball/2011-nba-season-start-655/

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Armstrong Clothes for Kids Project Donates Clothing to Military Families

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Source: savannahnow.com --- Monday, December 26, 2011
? What do you get when you combine motivated Armstrong volunteers, a great cause and a dash of holiday spirit? You get the Clothes for Kids project, which recently collected dozens of boxes of new and gently used children?s clothing for families at Hunter Army Airfield in Savannah. The Armstrong Atlantic University? Greek Council and the Educational Technology Training Center joined forces to organize this special service project, designed to make the holidays even brighter for local Military families. By collecting clothing for children from infants to age 18, Armstrong volunteers helped make a difference in the lives of others. Volunteers gathered at the Armstrong Center Dec. 9 to sort children?s clothing into boxes to donate to more than 175 area Military families. On Dec. 12 and 13, Hunter Army Airfield families who filled out an interest form in advance were invited to the Armstrong Center to pick up pre-packaged boxes of clothing. The Clothes for Kids Project set up clothing collection boxes on the Armstrong campus and at various sites throughout Savannah. Off-campus boxes accepted clothing at the Publix at Twelve Oaks Shopping Center, the Publix at Largo Plaza, the Big Lots on Abercorn Extension and the Savannah-Chatham Metropolitan Police Precinct at Oglethorpe Mall. ?We?re truly humbled by the support of Armstrong students and faculty and the community at large,? said Marshall. ?Thanks to the Clothes for Kids project, ar ...

Source: http://savannahnow.com/your-good-news/2011-12-26/armstrong-clothes-kids-project-donates-clothing-military-families

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Robert De Niro Welcomes A Baby Girl

Actor Robert De Niro is a dad again at age 68. Yep he and his wife announced they have welcomed a baby girl. Via a surrogate Robert De Niro and wife actress/singer Grace Hightower 56 years old, are now the proud parents of a baby girl, Helen Grace Hightower. Their new daughter joins big brother Eliot who is 13 years old. The little girl is apparently doing just fine. She weighed in at a healthy 7 pounds and 2 ounces. Robert and Grace have been married since 1997, however they separated in 1999 but their divorce was never finalized. In 2004 the couple renewed their vows and have been happily married since then. Little Helen is the sixth child for the Academy Award winning actor who has four other children. He has a son Raphael from his first marriage to Diahnne Abbott. Robert also adopted Diahnne?s daughter Drena from a previous relationship. Then there are his 16-year old twin boys Julian and Henry from his relationship with Toukie Smith. Well it certainly seems that De Niro and his family have even more reason to celebrate this holiday season with the addition of their new baby girl. What a great Christmas [...]

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/gWv7Yjuqi_Y/

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Microsoft OneNote for Apple iPad Review

?

After trying to ignore or repel the iPad for years, Microsoft has finally come around and released an Office app for Apple?s tablet with?OneNote for iPad. The app is free but limited. For starters, it comes with a limit of 500 notes, after which you?ll need to make a $14.99 in-app purchase to continue taking notes. For another, it feels as if Microsoft was afraid to let iPad users go full-bore with OneNote, holding some key features back and forcing you to use the PC or Web app for seemingly basic tasks such as creating new notebooks and sections, organizing notes, and assigning tags.

For current OneNote users that have an Apple iPad, it?s worth checking out, which isn?t high praise for a free app. For all others, it?s unlikely you?ll find OneNote for iPad up to the note-taking challenge.

Design
When you launch the app for the first time, you?ll need to log in using your Windows Live account or create a new one. Along with that, account comes 25GB of free online storage via Microsoft's SkyDrive service, which OneNote uses to sync files among your various devices.?

OneNote for iPad has a simple design. In portrait mode, a page of a spiral notebook fills the screen, with a menu bar at the top that features but four buttons. The Home button sits on the left, while buttons to delete, email, and create notes sit to the right. In landscape mode, you get a two-column design with the home button turning into a thin column on the left where you can navigate your various notebooks, sections, and notes.

In OneNote?s scheme, a notebook is filled with sections, which are filled with notes. On the app itself, however, you can create only notes. OneNote for iPad starts you off with one default notebook, awkwardly named Personal (Web). To create a new notebook or a new section within a notebook, you need to use the PC or Web app. Also, the app doesn?t let you move notes from one notebook or section to another.

Features
To create a note, tap the icon in the upper-right corner. This new note is placed in the Unfiled section of the Home menu. Again, to move these files into a notebook, you must use the PC or Web app. Perhaps you wouldn?t mind the inability to organize your notes on OneNote for iPad if the app allowed you to tag your notes. Sadly, a simple and effective tool like tagging isn?t supported. Again, you must scramble back to your PC or Mac to add tags to notes created on the iPad. Why the runaround, Microsoft?

If you have created notebooks with sections with the PC or Web app, you can then create a new note within a specific section with the app instead of to the Unfiled list. When you drill down to a section within a notebook, a "create" button appears in the upper-right corner of the Home menu. You can also swipe on a note from the list to delete it.

In addition to the Notebooks and Unfiled views on the Home menu, you can also view recent notes. Each item on this list has a grayed-out pin, which you can tap to pin the note to the top of the list. You can?t drag to reorder a list of notes, and the only way to see the date of a note is to open it (it?s listed in the upper-right corner). And while you can search by keyword, there is no way to search by date or even view notes by chronological order. OneNote doesn?t use the iPad?s location services, so neither can you search by location. Be sure you give your notes descriptive titles.

The app syncs automatically, but it?s not continual. It syncs when you move from one note to another note, but it doesn?t while you are busily typing away in a note. Changes you make to a note using the iPad app do not immediately show up in the note in the Web app, for example, and vice versa.

Note Taking
The keyboard appears when you tap on a note. It?s the standard iPad onscreen keyboard, with three additional buttons. One creates a checkbox next to a line of text, which you can then tap when that item is completed. The second button creates bulleted lists, and the third lets you embed a photos into a note, either by snapping one yourself right from the app or selected a shot from your library. If you work best with numbered lists, I?m sorry to report, you won?t find them here. Also, you can?t insert audio clips as you can with Evernote.

Oddly, there is not a way to remove a photo inserted in into a note, at least not one that I?ve found. Another annoyance is the inability to highlight more than one paragraph of text, which forces you to go line by line when creating a checklist or a bulleted list out of an existing free-form list.?

And that?s it for additional controls. Formatting options such as font, font size, font style and color, are not offered. There is no inking support either, and given the large screen of the iPad, being able to quickly scribble a reminder or draw a rudimentary diagram or any number of things, it would have been a welcomed addition.

CONCLUSION
It?s never a good sign when you spend more time discussing what an app can?t do than what it can. Note-taking apps need not be feature packed, and in fact, they are best when they are as simple as possible. While OneNote for iPad boasts a streamlined design and is easy to get in and out of, it lacks too many basic features to offer true utility. If you aren?t already using OneNote, then this app isn?t about to get you to start.

Pros It's free, and it's OneNote Streamlined design

Cons Very limited functionality? Missing basic features

Related Articles:

Source: http://www.tabletpcreview.com/default.asp?newsID=2901&review=apple+ipad+microsoft+onenote

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Video: Tech drives Calif. jobs growth

"Operation Gratitude" brings home to soldiers overseas

Eight years ago, Carolyn Blashek founded "Operation Gratitude," a volunteer organization that sends care packages to U.S. troops deployed overseas. Tracy Smith reports the remarkable story of one woman's mission to bring little bits of home to American soldiers in combat zones.

Source: http://feeds.cbsnews.com/~r/CBSNewsGamecore/~3/gav6AnJU_9U/

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'Marilyn' actor Branagh parallels his character (AP)

New York ? Long before Kenneth Branagh stepped into the role of Sir Laurence Olivier in "My Week With Marilyn," there already were strong parallels between them.

Both are synonymous with film adaptations of William Shakespeare, delivering lines with implausible realism, and earning accolades for their troubles. Each starred and directed their own successful adaptations of "Hamlet," and "Henry V," that earned Oscar nods for their work on both sides of the camera. (Olivier received an honorary award that included directing the film).

With such similarities, it seems fitting that Branagh earned a Golden Globe nomination for his performance as the legendary actor.

"He was a master of his craft, and at the same time very vulnerable," Branagh says of Olivier.

"My Week with Marilyn," is in theaters and stars two-time Oscar nominee Michelle Williams as Marilyn Monroe. It's based on the writings of Colin Clark, who spent a week with the iconic actress in 1957 while she was filming "The Prince and the Showgirl" in the United Kingdom.

"When they were making this film, Olivier, saw it as means to reinvigorate his career, especially in the states," Branagh said. "But he found it a challenge to work with Marilyn (Monroe), whom he considered less than professional."

Olivier eventually lightened up to Monroe, admitting she was wonderful in the film.

But Branagh says his co-star, Michelle Williams, who plays the iconic Monroe, has been wonderful from the start.

"Before we ever started filming, she learned everything she could about Marilyn, and played her flawlessly."

"After some time you live the character, and stop playing it," he added.

Olivier was 50 when he starred and directed "The Prince and the Showgirl," and Branagh was 50 when he portrayed Olivier in the film.

"He had this attitude of, `It's not over, yet,' and I feel the same way," Branagh said.

The actor always has held Olivier in high regard and is humbled whenever critics draw comparisons. That comes as no surprise when you consider Olivier's body of work. Classic performances include Heathcliff in "Wuthering Heights," the title characters in "Othello" and "Richard II," and Andrew Wyke from "Sleuth."

"How could you not be an Olivier fan? Just think of that scene in Marathon Man, where he's torturing Dustin Hoffman with a dentist's drill. That scene alone could be responsible for a generation of British not going to the dentist," Branagh said before breaking into laughter.

So while he's a serious actor, Branagh also has a good sense of humor. And he's going to need it at the Golden Globes, where Ricky Gervais returns as host.

Branagh and Gervais grew up in the same English town of Reading; Branagh moved there as a child from Belfast. Branagh is a year older than Gervais and says their schools often played football games against one another. Branagh was an avid footballer through school.

"I'm not sure if he ever played," the actor said of Gervais. "But if he did, we certainly played against one another."

Because of the hometown connection, Branagh expects Gervais to focus some the jokes about growing up in Reading. And the actor says he has no problem with that.

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111223/ap_en_mo/us_people_kenneth_branagh

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Action Movie FX App is Awesome, Free Fun (Mashable)

[brightcove video="1344414576001 " /] Admit it, you've always wanted to be an action star. I mean, who wouldn't want to effortlessly dodge flying cars, helicopters and missiles? Now, thanks to action auteur J.J. Abrams's new free app, Action Movie FX, and a little help from your iPhone, you can.

[More from Mashable: 1976 Letter from Potential Partner Calls Steve Jobs a ?Joker? [VIDEO]]

The app launched in Apple's App Store just a day after Abrams big-screen actioner Mission Impossible 4: Ghost Protocol hit theaters. Abram's Bad Robot produced and Brad Bird directed (and Mashable hit the red carpet premiere). Included effects are "inspired by" the film. It's obviously designed to appeal those who would not only love to see Tom Cruise's latest film, but wouldn't mind starring in it too.

Action Movie FX [iTunes link] is an incredibly simple app that accomplishes an impressive feat: It puts you in the middle of the action. Here's how it works: You open the app and select one of two free action effects: Missile Attack and Car Smash. You can purchase additional effects for 99 cents apiece. After you've selected the scene, you shoot a short video. The apps offers some guidance and how and where to shoot (shoot over flat surface if you want the missile to land properly). It also offers a handy screen overlay that shows you approximately where the effect will occur in your clip.

[More from Mashable: 6 Crazy Tech Predictions for 2012]

It's also helpful if you have someone else hold the camera. All they have to do is hit the big red record button, hold the camera steady and record. I'd suggest recording a minute or less since most of the effects are pretty brief. Once the video is recorded, Action Movie FX offers an effects slider that lets you adjust where in your recording to start the effect. Next, you process the film and preview. You can still go back and adjust the timing until the effect hits at just the right moment.

The final product is a hoot -- the effects overlay is near perfect. You can save locally to your own camera roll, email, or share via Facebook.

The app requires iOS 4.3 or later and works with the iPhone 3GS, iPhone 4, iPhone 4S, iPod touch (4th generation), iPad 2 Wi-Fi and iPad 2.

I made my own brief effects-laden film (and could have done a better job positioning the camera), and I encourage you iPhone owners to do the same. If you do make your own video, we'll make an exception to our "no HTML" rule if you'll paste the link to it in the comments below, so we all can enjoy your artistry.

This story originally published on Mashable here.

Source: http://us.rd.yahoo.com/dailynews/rss/applecomputer/*http%3A//news.yahoo.com/s/mashable/20111223/tc_mashable/action_movie_fx_app_is_awesome_free_fun

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PogoWasRight: RT @adamshostack: I hear Boston police have also issued @twitter subpoenas for @paulrevere, @samadams & @johnadams http://t.co/CCAZIaa9 ...

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I hear Boston police have also issued @twitter subpoenas for @paulrevere, @samadams & @johnadams bit.ly/sxyHXW (/cc @amac) Il y a environ 8 heures via TwitBird Retweeted by 2 people

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RKleckler: RT @BradLawless: I'm hiring! Controller at Collective Bias - Fayetteville, Arkansas Area #jobs http://t.co/mfBXwqJl

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Flacco leads Ravens to 20-14 win over Browns

/

By DAVID GINSBURG

updated 6:15 p.m. ET Dec. 24, 2011

BALTIMORE - Eight games, eight wins. The Baltimore Ravens achieved perfection at home for the first time, and now they're looking to add to that ledger in the playoffs.

Joe Flacco threw two touchdown passes, and the Ravens beat the bumbling Cleveland Browns 20-14 on Saturday to move one step closer to winning the AFC North.

Ray Rice ran for 87 yards and caught a TD pass for the Ravens (11-4), who led 17-0 at halftime and held on.

"I have never been perfect at home in 16 years of football. That's amazing," Baltimore linebacker Ray Lewis said. "As good of teams we've had here, we've always found (a way) to lose one or two here or there. I think this year we really made a focus on taking care at home. This is the result, us being able to go 8-0 and being able to be sitting where you want to sit at the end of the day."

The Ravens would win the AFC North by defeating Cincinnati on the road next week. That would also give Baltimore a first-round bye and a home playoff game ? two if New England loses next Sunday at home against Buffalo.

"It's big, man," linebacker Terrell Suggs said. "We are at our best when we are at (home) and our fans are rocking. So we definitely need a home playoff game, by any means necessary."

Flacco went 11 for 24 with touchdown passes to Rice and tight end Ed Dickson. He also had a 33-yard run.

Josh Cribbs had a career-high 84-yard punt return for a TD for Cleveland (4-11). But the Browns generated very little offense and were guilty of questionable play calling, bad clock management and untimely penalties in their fifth straight loss.

Cleveland saved the worst for last. Having already burned their three timeouts, the Browns lined up on defense after the two-minute warning with the Ravens facing a fourth-and-2 at the Cleveland 37.

It appeared obvious that Flacco and the Ravens were merely hoping to draw the Browns offside.

As the play clock moved close to zero, Cleveland tackle Phil Taylor jumped across the line of scrimmage to give Baltimore a first down.

"It was the first hard count and we stayed onside," Taylor said. "The second time, I just jumped. Of course you feel bad, but you just got to move on."

Said Flacco: "I don't know if I've ever been in position for that to happen. It's never worked."

The Ravens then ran out the clock on their eighth straight win over the Browns, including two this month.

"We knew this would be quite a challenge for us," Cleveland quarterback Seneca Wallace said. "We're playing the Ravens at home, and they're playing for everything. I should have played better, and I should have made better decisions."

Wallace went 19 for 33 for 147 yards in place of Colt McCoy, who was out with a concussion. Peyton Hillis ran for 112 yards, but Cleveland's offense mounted only one decent drive.

The Browns took the opening kickoff and moved from their own 26 to the Baltimore 30 behind the power of Hillis, who gained 30 yards on six carries. But on a third-and-1, Cleveland inexplicably went to the air, and Lardarius Webb intercepted Wallace's pass for Mohamed Massaquoi.

Flacco immediately threw deep for Torrey Smith, who drew a 60-yard penalty for pass interference on Mike Adams to set up a 5-yard touchdown pass to Dickson.

Later, a 29-yard throw from Flacco to Smith led to a 48-yard field goal by newcomer Shayne Graham, signed in the middle of the week to take over for the injured Billy Cundiff.

After another Cleveland punt, Flacco directed an 82-yard drive that gave Baltimore a 17-0 lead. Rice slipped behind linebacker D'Qwell Jackson on the right sideline, caught a soft pass in stride and sprinted into the end zone to complete a 42-yard scoring play.

That made Flacco 5 for 5 for 94 yards and two touchdowns on third down.

Cleveland moved deep into Baltimore territory late in the first half, thanks in part to a 30-yard pass interference call against Chris Carr. But with the clock inside 10 seconds and the Browns without a timeout left, Wallace handed off to Hillis instead of spiking the ball, and Hillis went nowhere.

Wallace took the blame, and so did Browns coach Pat Shurmur.

"I need to communicate it better, OK?" Shurmur said.

Time expired before Cleveland could get off another play, and the Browns headed to the locker room after being held scoreless in the first half for the second time this season. The other time it happened was also against Baltimore.

Graham kicked a 43-yard field goal in the third quarter to make it 20-0.

The Browns finally scored when Cribbs took a punt on the right sideline, escaped an arm tackle and broke toward the center of the field before outrunning three defenders into the left corner of the end zone late in the third quarter.

"I was wondering where all the defenders were," Cribbs said. "I saw all the great blocking around me. From there, it was easy. It was just a walk in."

Cribbs also contributed to Cleveland's next touchdown, catching a 23-yard pass from Wallace as part of an 80-yard drive that ended with a 9-yard TD throw to Evan Moore midway through the fourth quarter.

The Browns forced a punt, but on a fourth-and-4 from the Cleveland 45 with 4:03 left, a pass to Hillis did not produce the necessary yardage.

Taylor's jump across the line of scrimmage soon followed.

NOTES: Ravens KR David Reed hurt his left knee and declared himself out for the season. Also, Baltimore OT Marshal Yanda (chest) and CB Cary Williams (concussion) did not play in the second half. ... Shurmur said the Browns sustained no serious injuries. Cleveland closes the season next Sunday against Pittsburgh.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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'It's time to shut up, fat boy'

PFT: The Jets-Giants trash talk didn?t end after the Giants win on Saturday. According to multiple reports, Brandon Jacobs and Rex Ryan got into a yelling match after the game.

Giants stay alive, put Jets on ropes ?|? Kings of NY

Victor Cruz set two franchise receiving records, and Ahmad Bradshaw ran for two touchdowns as the Giants kept their playoff hopes alive by winning the New York-area bragging rights with a 29-14 victory over the Jets on Saturday.

Source: http://nbcsports.msnbc.com/id/45784637/ns/sports-nfl/

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Iraq president demands fair trial for VP

Tunisian government sworn in
TUNIS, (AFP) Tunisia's new government was sworn in on Saturday by the country's president, who told the ministers to get straight down to work. Headed by Prime Minister Hamadi Jebali of the moderate Islamist Ennahda party, the 30 ministers and 11 ... more Iraq president demands fair trial for VP
BAGHDAD, (AFP) Iraq's President Jalal Talabani said Saturday that the country's Sunni vice president, who stands accused of running a death squad, would stand trial only if promises were made regarding its fairness. His remarks come with the country ... more Egypt Islamists sweep second round of election
CAIRO, (AFP) - Egypt's main Islamist parties won 65 percent of votes for party lists in the second round of a historic election for a new parliament after Hosni Mubarak's ouster, the electoral committee said Saturday. The Freedom and Justice Party won ... more Hamas and Fatah both made mistakes Hamas chief
Cairo, Asharq Al-Awsat Hamas chief Khaled Meshal called on Palestinian factions, particularly the Hamas and Fatah movements, to have the courage to criticize themselves and bear the responsibility for the mistakes they have made in the past. Speaking ... more US has found 5,000 missiles in Libya
WASHINGTON, (AFP) US experts sent to Libya to recover weapons left over by the regime of fallen leader Moamer Kadhafi have found about 5,000 surface-to-air missiles, the State Department said Friday. The exact number is difficult to say, said spokesman ... more Cold war heats up between Washington and Hezbollah
BEIRUT, (AFP) A war of words is heating up between Hezbollah and Washington, with allegations and counter-allegations flying between the two foes as the crisis in Syria takes its toll on the Shiite militant group. The cold war between Iranian- and ... more Muslim Brotherhood denies Syria bombing claim
NICOSIA, (AFP) Syria's Muslim Brotherhood on Saturday denied an Internet claim of responsibility that it was behind suicide bombings in Damascus, saying the claim was posted on a fake website created by the regime. Spokesman Zuhair Salem, speaking ... more Egypt activists gather for mass rally against army
CAIRO, (Reuters) - Egyptian protesters gathered in Cairo for a mass rally they called for on Friday against the military's handling of protests that killed 17 people and have drawn international criticism of the ruling generals. Protesters who fought ... more Twin suicide bombings kill 40 in Damascus: Syria
BEIRUT, (Reuters) - Suicide car bombers struck Damascus on Friday, officials said, killing 40 people, gutting buildings and sending human limbs flying in the bloodiest violence seen in Syria's capital since a revolt against President Bashar al-Assad ... more Iraq talks cancelled after deadly bombings
BAGHDAD, (AFP) Crisis talks between political leaders set for Friday, a day after Iraq's worst attacks in four months, were cancelled amid a worsening row that has seen its premier threaten to dissolve power-sharing. Sunni Vice President Tareq al-Hashemi, ... more U.S., Pakistan share blame in border deaths - U.S. probe
WASHINGTON, (Reuters) - A U.S. probe on Thursday found both American and Pakistani forces were to blame for a border incident that killed 24 Pakistani troops last month, inflaming already strained ties and deepening doubts about whether Pakistan will ... more Hezbollah denies drugs, money laundering claims
BEIRUT, (AFP) Lebanese group Hezbollah on Thursday denied charges by the United States that the Shiite militant movement was involved in drug trafficking and money laundering schemes to fund its activities. "The United States' allegations that Hezbollah ... more Hamas says it plans to join Abbas's PLO
GAZA, (Reuters) - Rival Palestinian factions took a significant step towards reconciliation on Thursday as the Islamist group Hamas said it planned to join Western-backed President Mahmoud Abbas's Palestine Liberation Organization (PLO). Abbas held ... more World leaders bid farewell to Vaclav Havel
PRAGUE, (Reuters) - International leaders bade farewell on Friday to former Czech President Vaclav Havel, the anti-communist dissident who led the peaceful "Velvet Revolution" and inspired human rights campaigners around the world. Secretary of State ... more Afghan president to replace top human rights officials
KABUL, (Reuters) - Afghan President Hamid Karzai will replace four people at the national human rights commission to bring fresh blood into the group, and not because he is seeking to remove some of his most outspoken critics, his spokesman said on Friday. The ... more We must re-examine peace treaty with Israel - Egyptian Judge
Alexandria, Asharq Al-Awsat Judge Mahmoud al-Khudairi is the former vice president of the Egyptian Cassation Court. He is also a newly-elected member of the Peoples Assembly, having won the seat of the Sidi Gabir district, Alexandria, in the latest ... more Fatah, Hamas leaders debate PLO reform in Cairo
CAIRO, (AFP) Palestinian president Mahmud Abbas and Hamas leader Khaled Meshaal met on Thursday to discuss reforming the Palestine Liberation Organisation (PLO) in a bid to allow the Islamist movement to join. The two men began meeting in Cairo ... more Qaeda leader's brother among 11 dead in Yemen
ADEN, (AFP) The brother of an Al-Qaeda chief was among six militants killed in the restive southern Yemeni province of Abyan, where five soldiers also died in overnight clashes, local officials said on Thursday. Five Qaeda suspects died when their ... more Egypt PM urges unity for sake of economy
CAIRO, (AFP) Prime Minister Kamal al-Ganzouri called on Egyptians on Thursday to set aside their political differences for the sake of the economy, warning that the country's finances were deteriorating alarmingly. The appeal came a day after Moody's ... more

Source: http://www.aawsat.com/english/news.asp?section=1&id=27827

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Gingrich Will Attempt to Mount Write-in Campaign for Virginia GOP Primary

• By Jason Dick
• Roll Call Staff
• Dec. 24, 2011, 11:22 a.m.

Bill Clark/CQ Roll Call File Photo

Updated: 1:15 p.m.

The presidential campaign of former Speaker Newt Gingrich today blamed "a failed system" for the Georgian's inability to qualify for the Virginia Republican primary next year, vowing to pursue a write-in campaign to secure its candidate's place on the ballot.

Gingrich and Texas Gov. Rick Perry failed to submit the required 10,000 valid signatures to qualify for the ballot, the Republican Party of Virginia announced late Friday.

"Voters deserve the right to vote for any top contender, especially leading candidates. We will work with the Republican Party of Virginia to pursue an aggressive write-in campaign to make sure that all the voters of Virginia are able to vote for the candidates of their choice," Gingrich Campaign Director Michael Krull said in a release. However, the commonwealth does not allow write-ins in its primary elections."

Former Massachusetts Gov. Mitt Romney and Rep. Ron Paul (Texas) qualified for the ballot, having turned in the required number of valid signatures.

The Virginia Democratic Party announced Friday that President Barack Obama also submitted the required number of signatures. Furthermore, the party said that because Obama is the only Democratic candidate for president, the State Board of Elections is expected to cancel its primary and allow the Commonwealth's Democrats to forward all their delegates to the national convention to cast their vote for him.

Source: http://www.rollcall.com/news/Gingrich-Will-Mount-Write-in-Campaign-for-Virginia-GOP-Primary-211265-1.html

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