The White House and the State Department said on Friday a new Israeli settlement expansion plan was "counterproductive" and could make it harder to bring Israel and the Palestinians back to the negotiating table.
Source: http://www.msnbc.msn.com/id/40153870/vp/50033245#50033245
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LUCID by LinenSpa 10 is just a pure luxury that anyone can enjoy at the reasonable prices. The thickness of this mattress is about 10 inches along with the plush memory of 2.5 inches and its weight is 3.0lbs. It features an extremely soft and comfortable base of 7 inches which is made from the polyurethane. All these layers work on the open cell technology that allows an uninterruptible air flow through the different layers of this memory foam mattress. This technology keeps you comfortable and cool while you sleep after a busy day.
The open cell construction of the LUCID mattress foam yields more resilient and long lasting foam that will not leave the body impressions for longer periods. The doughy, soft consistency of this foam conforms to pressure and weight very quickly. This mattress is also highly advisable for the persons who are experiencing the shoulder, back and neck pain. It can do this by reducing the pressure points. Following are some other pros of using the LUCID by LineneSpa 10? memory foam mattress.
Good for the side-lying sleepers:
According to an estimate more than 73 percent people sleeps on their side. The memory foam mattress are usually recommended for these persons because they provide the most appropriate way to maintain the natural shape of the curves of the shoulders and hips and spine while sleeping.
The LUCID mattress helps in dispersing the weight and cradling the body across the maximum surface area, rather than creating the sensitive pressure points at the shoulders and hips. In these cases, the special pillows may also be very supportive in positioning the neck parallel to the ground.
Antimicrobial resistant:
Actually, this foam is designed in a way that makes it naturally resistant to the allergens and antimicrobial. It has the competence to save you from the living organisms like bacteria, mold and other dirt mites. The yielding velour zip-off covers of the LUCID mattress id anti dust mite and antimicrobial that can be easily laundered and removed whenever you want.
Fibromyalgia and arthritis:
The patients who are suffering with the multiple painful joints must consider the memory foam mattress. The reason behind it is that it disperses the weight of a patient in the maximum surface area. The patients of Arthritis also have the so many complaints in their spinal. Balancing the cushioning with the appropriate support for the spine needs a mattress of high-end or utmost quality and when it comes to the top quality mattress then the one and only name instantly come into the mind that is the LUCID memory foam mattress.
Stomach sleepers:
The persons who sleep on their stomach on the soft bed can produce a great stress on their thoracolumbar spine. The weight of the pelvis and belly also compress the whole bed. The memory foam mattress provides firmer support to the thoracolumbar, pelvis and stomach areas of these patients. So, if you are a stomach sleeper, then just go with the LUCID memory foam mattress.
Source: http://www.cornthai.com/lucid-by-linenspa-10-memory-foam-mattress-review/
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LOS ANGELES (TheWrap.com) - "The Dark Knight Rises" and "The Hobbit: An Unexpected Journey" have made it onto the short list of contenders for Oscars in the Visual Effects category at the 85th Academy Awards, the Academy said Thursday.
The films are included on a list of 10 remaining contenders, a list that also includes "The Amazing Spider-Man," "Cloud Atlas," the big-screen bomb "John Carter," "Life of Pi," "The Avengers," "Prometheus," "Skyfall" and "Snow White and the Huntsman."
Members of the Academy's Visual Effects Branch will be given the opportunity to view 10-minute excerpts from the remaining contenders on January 3, after which they will vote for the five films that will be considered for Oscars.
Oscar nominees will be announced January 10, with the Academy Awards ceremony taking place February 24.
Source: http://news.yahoo.com/dark-knight-rises-hobbit-short-list-visual-effects-001406681.html
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NEW YORK (Reuters) - Lindsay Lohan was arrested outside a New York nightclub on an assault charge early Thursday after she punched another woman in the face, police said, marking another legal dustup for the 26-year-old "Mean Girls" actress.
Lohan and the 28-year-old unidentified woman had some sort of a dispute inside the club Avenue in Manhattan's Chelsea neighborhood around 4 a.m., police said.
Lohan, who has faced a series of legal and financial troubles in recent years, punched the woman in the face multiple times, said New York Police Sergeant John Buthorn, adding that the victim sustained "minor, minor injuries."
Lohan was arrested on a third-degree misdemeanor assault charge, police said.
She was released from police custody later on Thursday morning. Wearing a green, knee-length dress, black tights and high heels, Lohan was hustled from NYPD's 10th Precinct House with a personal security guard's blazer draped over her head and into a waiting SUV, which quickly drove away.
She will have to return to court at a later date to face the charge, police said. Calls and an email to her publicist were not immediately returned.
The arrest came during an already rough week for Lohan, whose latest performance as Hollywood screen legend Elizabeth Taylor in the TV movie "Liz & Dick" was panned by critics. Cable TV channel Lifetime said on Monday that a modest 3.5 million Americans watched the film that premiered last weekend.
Earlier this month she canceled an in-depth interview with ABC's Barbara Walters, who said she suspected the actress' publicity team pulled the plug knowing Walters would ask tough questions.
Lohan's recent visits to New York have been peppered with run-ins with police and public spats.
Last month police were called to the Long Island home of Lohan's mother, Dina Lohan, where she and her mother had become involved in a loud, early-morning argument. Nassau County Police left the scene without making any arrests.
In September Lohan was arrested in Manhattan after a pedestrian told police that her Porsche had struck him in an alley.
She was initially charged with leaving the scene of an accident, a misdemeanor, but a late-October court date was canceled and another date was not scheduled, an indication prosecutors decided not to proceed with that case.
Also in September, she scuffled with a man at a New York hotel over what media reports described as her demand that photographs he had taken of her be deleted from his cellphone.
(Reporting by Colleen Jenkins and Dan Burns; Editing by Xavier Briand)
Source: http://news.yahoo.com/lindsay-lohan-arrested-york-accused-punching-woman-130651914.html
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Google?s (GOOG) Android platform clearly dominates the mobile landscape in terms of market share, and though Samsung (005930) continues to close in, Apple (AAPL) leads the pack in profitability by a wide margin. According to one industry watcher, however, they should all be watching out for Microsoft (MSFT).
Sizemore Capital?s?Charles Sizemore writes in a contribution to?NASDAQ that ?Microsoft will ultimately muscle-out Apple as the leader in smartphones and tablets.? He says the war will be long and grueling, but Microsoft will ultimately pull ahead because Apple has no??durable long-term advantages? to keep customers loyal. He also contends that ?Apple?s insistence on controlling every aspect of both its software and hardware puts it at a disadvantage to a more flexible Microsoft.?
Where Android is concerned, Sizemore says he doesn?t take Google seriously as a long-term competitor because the company?s solutions are ?shoddy? attempts at matching superior offerings from Apple and Microsoft. He points to Google Play Music as an example, though the extent of his complaint seems to be that the app can?t cache music on an SD card as opposed to a device?s internal storage without the user ?hacking? his or her phone. The analyst offers no further examples to substantiate his claims.
?You simply don?t have these sorts of problems with Apple or Microsoft,? Sizemore contends. ?Why? Because they are real companies with real business models. With a few exceptions, they actually charge for their products and offer some degree of support.?
He continues, ?Given that Google gives most of its products away for free, you have to question how seriously they take them. And given my experience with Play Music, the answer is ?not very.? ?
The analyst concludes that while he is not forecasting an ?immediate collapse in Google?s share price,? he finds no evidence to show that Google?s advertising model is sustainable and therefore will not invest in Google. Sizemore discloses that his firm?holds a long position in Microsoft.
Get more from BGR.com: Follow us on Twitter, Facebook
Source: http://news.yahoo.com/microsoft-crush-google-muscle-apple-smartphone-tablet-markets-172022575.html
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If you're reading this from New York City, it's time to close that laptop lid and head down to our reader meetup at Roseland Ballroom! The party is just getting started, and we'll be here until 10 tonight. There's plenty of food, drinks and an absolutely insane number of gadgets to give away. For those of you stuck at home, we hope to see you at another event in the very near future, but for now, you can click on through to our liveblog to catch all the action from Manhattan.
Filed under: Announcements
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/x6EQ-_uMJpY/
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Diabetes affects all parts of the body, causing an imbalance in the function and efficiency of the affected part. Diabetes is high blood sugar level of the normal limit.
Sexual ability for diabetics, whether man or woman 'will be adversely effected as a result of being infected with the disease, but the focus is more on the damage that gets men. And the absence of information when a lot about the effect of diabetes on the ability of women's sexual and which may be more severe and impact on marital life.
The problem is that many doctors are reluctant to discuss the impact of diabetes on women's sexual ability, unlike the case with men.
According to a study published in 2010 in the journal Diabetes Care that nearly half of men with diabetes had discussed the problem of poor sexual ability with the doctors, only 19% of women who suffer from diabetes have touched on the subject with your doctor.
Sexual problems associated with diabetes in women include decreased libido, reduced sense of fun sexual . When the level of sugar in the blood is controlled to cause damage to cells micro vascular nutrients to the nerves with the passage of time, and increased blood glucose starts to destroy the myelin - a protein that covers nerves.
Thus causing damage to the nerves as a result of a lack of awareness vessels which will ultimately result in weakness in the sense of the pleasure of orgasm or chills that occur as a result of urine muscle contraction in women when having sexual intercourse.
Also cause diabetes autonomic neuropathy, which affects the nerves in the stomach and urinary tract and pelvic nerves directly responsible for sexual stimulation.
The other problem caused by diabetes is vaginal dryness due to lack of secretion of gunk that eases the process of sex with men because of infections that infect the vagina as a result of reduced blood flow to the genitals and vaginal tissues, and hormonal changes.
As well as severe pain during intercourse, resulting in a reduced sense the pleasure of shaking, feel sexual enough. Affecting the marital relationship and the ensuing social problems. Many women do not realize that these problems may be from diabetes complications.
To manage these problems need to be done in several steps, including:
? Control of glucose levels in the blood as effectively as possible, through adherence to dietary health and physical activity
? Talk with your partner to work together to improve sexual contact
? Control the level of blood pressure and cholesterol at the natural limit
? Refrain from smoking
Author's Bio:?
I'm Abdulrazaq Al-Jobori . Holds BSC degree in Food Science and Technology ,member at the International Union of electronic media(Uniem ).Working in promotion health field as freelance writer at health, nutrition and fitness topics in Arabic and English language for websites, blogs, newspapers and magazines.
Source: http://www.selfgrowth.com/articles/diabetes-and-womens-sexual-health
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Gus Van Sant has been fairly quiet in the past few years, with his only directorial feature being Restless,?which was pretty big flop. Recently though, with the hype building for?Promised Land,?it seems that Van Sant may again be as relevant as he once was. To follow up?Promised Land,?he has an interesting project in the works: a martial arts superhero film.
Movie Line?reports the director is currently working on the script of a Stephen Chow (Kung Fu Hustle)?inspired film. From what we know, the story focuses on a group of normal citizens who develop the skills to take on crime.
The story has an extremely specific location, Hollywood Boulevard and Gower, near the Pep Boys sign, which is where?Van Sant says he got the inspiration for the film. He was standing next to a frail old woman holding an armful of bags, when he had the following thoughts.
?I thought, Oh my God, she?s going to get hit, and then I thought that maybe she has more going on than I think. Maybe I should give her more credit. Maybe she could kick my ass.?
So is this a film about the elderly martial arts experts of Los Angeles? Not quite, but it will be normal people who set out to clean up a small area of the city, meaning there probably won?t be a sinister?super-villain?setting out to destroy the world. But then again, it sounds like the story still could undergo drastic development.
Van Sant says the script is nowhere near ready for shooting, but he?s been creating some watercolor paintings of the characters on Hollywood Boulevard, that he hopes will inspire the eventual shoot. Writing, directing, and painting? Quite the?renaissance?man.
What do you think of Gus Van Sant taking on this genre? Are you interested in his martial arts superhero film? Share your thoughts in the comments section below.
Source: http://www.rottentomatoes.com/m/1926349/news/1926349/
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Charla Nash, who was the recipient of a groundbreaking full face transplant in 2011 after an attack by a chimpanzee left her disfigured, talks about gaining more feeling in both sides of her face and building stamina with the hope of undergoing a hand transplant by Christmas.
By Dave Collins, Associated Press
HARTFORD, Conn. --?Lawyers for a woman mauled by a chimpanzee in Connecticut have agreed to a settle a lawsuit against the estate of the primate's now-dead owner, according to court documents obtained Thursday by The Associated Press. Terms of the deal were not disclosed.
Attack victim Charla Nash's brother filed the lawsuit on her behalf in 2009 in state Superior Court seeking $50 million in damages from chimp owner Sandra Herold, who died in 2010. Nash was blinded, lost both hands and underwent a face transplant after being mauled outside Herold's home in Stamford in February 2009.
Lawyers for Nash's twin brother, Michael Nash, accused executors of Herold's estate earlier this week of withholding information needed to complete the settlement, according to a court document obtained by the AP.
An attorney for Herold's estate said Thursday that his office has since provided the information and the settlement is nearly finalized. He declined to elaborate and said the settlement will be confidential.
"The case is resolved," said Brenden Leydon, a Stamford lawyer representing Herold's estate. "I think it was a fair compromise on all sides."
Leydon had argued that Herold's estate couldn't be sued because Charla Nash was an employee of Herold and any claims were a worker's compensation matter.
Messages were left Thursday for Michael Nash and his lawyer. Charla Nash's other brother, Stephen Nash, declined to comment.
Chimp attack victim speaks about new face, new hopes??
AP
Charla Nash was severely disabled after she was attacked by a friend's chimp. See how she looked before, and what she looks like now, after a face transplant.
Charla Nash, 57, now lives in a nursing home outside of Boston. She had gone to Herold's home on the day of the attack to help lure Herold's 200-pound chimpanzee, Travis, back into her home. But the animal went berserk and ripped off Nash's nose, lips, eyelids and hands before being shot to death by a police officer.
Travis had starred in TV commercials for Old Navy and Coca-Cola when he was younger and made an appearance on the "The Maury Povich Show." The chimpanzee was the constant companion of the widowed Herold and was fed steak, lobster and ice cream. The chimp could eat at the table, drink wine from a stemmed glass, use the toilet and dress and bathe himself.
A month after the mauling, Nash's family sued Herold for alleged negligence and recklessness. The lawsuit alleged Herold knew Travis was dangerous but failed to confine him to a secure area and allowed him to roam her property. It also claimed Herold gave the chimp medication that exacerbated his "violent propensities."
Behind the scenes with the real Charla Nash??
Travis had previously bitten another woman's hand and tried to drag her into a car in 1996, bit a man's thumb two years later and escaped from her home and roamed downtown Stamford for hours being captured in 2003, according to the lawsuit.
Nash's family is also trying to sue the state for $150 million but is awaiting permission from the state claims commissioner. The state is immune from lawsuits unless they're allowed by the claims commissioner.
Nash wants to sue the state Department of Energy and Environmental Protection, which she holds responsible for not seizing the animal before the attack despite a state biologist's warning it was dangerous.
"I hope and pray that the commissioner will give me my day in court," Charla Nash told reporters following a hearing in August before Claims Commissioner J. Paul Vance Jr. She added that she hopes "this never happens to anyone else again. It is not nice."
Court documents obtained by the AP on Thursday show the settlement between Nash's family and Herold's estate was approved Sept. 25 by the Stamford Probate Court and the two sides met Nov. 13 to finalize it.
A lawyer for Michael Nash, Matthew Newman, said in a court document filed Tuesday that since Nov. 13, "executors have failed and refused to provide information necessary to complete the settlement."
Leydon said Thursday that Newman now has the needed information.?
Charla Nash, who was mauled by her friend's pet chimpanzee in 2009, has undergone a groundbreaking face and double hand transplant.? Her brother Stephen and daughter Briana talk about her remarkable recovery and show pictures revealing her new face.?
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? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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As with anything in life, things usually get done better and faster when a team effort is put forth.? The same is true for the real estate field.? One person cannot get a house closed on their own, it takes the hard work of many.? All successful REALTORS got to where they are today by building a great team around them.? There are several different players on the team that is real estate, the realtor, lender, attorney, home inspector and? insurance agent.? If all of these people do not have the common goal in mind to do everything possible to get to the closing table than deals can easily fall apart.? Realtors don?t just drive around in nice cars and show houses all day, they oversee the real estate transaction from start to finish and make sure all of the parties involved are on track to accomplish the goal set forth.?? By setting up a network or team of people who work well together and are top? industry professionals you are giving your clients a better chance of reaching their real estate goals.
I have been on a lot of teams in my life and I would have to say team CG is the best one by far.? Led by the broker ?Coach? Chris Grant.? He has set up an amazing network of agents who all work together to better the business and who put their clients needs ahead of their own.? Real Estate can be a? very cut throat business but I have never seen that here.? Everyone is always willing to help each other out.? CG Real Estate has also created lasting business relationships with other top industry professionals who have the same passion to help others.
If you are looking to buy, sell, invest, rent or just speak with an agent, CG Real Estate is the company for you.
?Why have one agent when you can have 30??
Source: http://www.cgrealestate.net/cg-real-estate-blog/there-is-no-i-in-real-estate
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By Yiran Zhao
Lansing Star staff writer
Preuss Pets
LANSING ? Preuss Pets, located at the intersection of N. Cedar St and E. Grand River Ave., have a wide range of pet supplies.
Whether you want to have another salt water fish, build a personal aquarium, or find your children some furry friends, Preuss Pets have it all. Kittens, hamsters, guinea pigs, parrots, if the store does not have what you were looking for, feel free to ask the shop assistant or the owner to place an order for you. If sources are available, Preuss Pets will contact you through phone call or email in no time.
1127 N. Cedar St
Lansing, MI 48906
Phone: (517)339-1762
Fax: (517)339-9520
Email:
General questions: info@preusspets.com
Bird room: birds@preusspets.com
Reptile/small animals: reptiles@preusspets.com
Fish: fish@preusspets.com
Open Monday to Saturday: 10 a.m. to 9 p.m.
Sunday: 11 a.m. to 6 p.m.
Free private parking lot
Click here to see their website
Click here to check their Facebook page
This entry was posted in Business, Local. Bookmark the permalink.Source: http://news.jrn.msu.edu/lansingstar/2012/11/28/preuss-pets/
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Health officials are trying to figure out if the virus is moving from person to person
Image: BioWiki
Maria Zambon was having d?j? vu. Earlier this fall, she found out about a new coronavirus that had come seemingly from nowhere to kill a Saudi man in Jeddah in June and seriously sicken another.? The survivor had been flown from Qatar to a London hospital. His lungs were overwhelmed with infection, his kidneys failing. Virologists at Erasmus Medical Center (EMC), in Rotterdam, the Netherlands, were already working on an isolate from the Saudi man to decode the virus's genetic sequence. They named the virus HCoV-EMC, short for human coronavirus and the institution's initials.
The situation reminded Zambon, director of reference microbiology for Britain's Health Protection Agency, of the SARS outbreak of 2003, which spread from China to as far as Toronto and killed 916 people. Fortunately, the recent coronavirus appears to be emerging more slowly than SARS did (also a coronavirus). To date, only six cases have been reported?four in Saudi Arabia and two in Qatar. Two of the infections have been fatal. The gnawing concern, however, is that the virus will start spreading from person to person, fanning out more broadly to infect people around the globe.
A recently discovered cluster of illnesses in Saudi Arabia has raised concerns that the virus may be able to move from person to person. Four men who lived in the same household in Riyadh became sick with similar symptoms within a short period of time. Two of the men tested positive for the virus. The two others?one of whom died?are currently classified as probable cases. Their infection status may remain ambiguous. With the source of the infection unknown and the incubation period unclear, authorities may never get a definitive answer about whether these family members were all infected from a common source, or whether one of them got sick and infected the others, says Anthony Mounts, the World Health Organization's technical expert for the outbreak.? "It sure raises your concern. But it's not definitive." If the virus spread from person to person in that Riyadh household, it has apparently since sputtered and died out.
Still, the discovery of additional cases, some in a cluster, has prompted WHO to cast a wider net in its search for other cases. The Geneva-based global health agency had initially warned countries to be on the lookout for cases of severe and unexplained respiratory illness in people who had visited or were residents of Saudi Arabia and Qatar. Now it is convinced that whatever the source of the virus is, it is probably not unique to those countries. By getting health authorities around the world to look harder for possible cases, it hopes to answer another question that people like Mounts and Zambon have been asking themselves: Is this virus actually new, or has it just newly come into view? If it is the former, then worries about what the virus might do will remain high.? But if it has been infecting people for years but was only spotted because two severe cases brought it to light, then the virus may seem like less of a threat.
"There's always a question of 'Well, actually, has it been around forever and a day and we just missed it because we haven't tested?'" Zambon notes. It is commonly accepted that medical science has not identified all the bugs that make people sick. In fact, before the SARS outbreak, only two viruses in the coronavirus family were known to infect people. In the years after SARS became the third, the human coronaviruses NL63 and HKU1 were added to that list.
Finding the answer means testing more patients with similar symptoms to see if they too are infected with the EMC virus. Some countries?Britain among them?have been testing sick pilgrims returning from this year's Hajj, the world's largest annual pilgrimage that brings roughly three million Muslims to? Mecca every year. So far there have been no reports of additional cases among the returning Hajjis. And as time passes, concerns about the pilgrimage as a disease-amplification opportunity are starting to wane. "The government of Saudi Arabia does quite extensive surveillance during the Hajj and was particularly vigilant during this season. They have reassured us that nothing unusual happened," Mounts says.
Source: http://rss.sciam.com/click.phdo?i=2f05c66840936867a50066d9fa77ae47
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Kevin Clash resigned from his three-decade career as a master puppeteer for the Sesame Street Workshop after a public sex scandal -- but he is not without his supporters.
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Now getting traffic to your website doesn?t have to be hard. All you have to do is follow a few simple techniques that will allow you to have the most success as possible in your internet business. I?ve been doing this for a long time now, and I can honestly tell you that if you want to get more new sales, you have to drive more and more traffic to your website on a consistent basis.
In today?s lesson, I want to share with you some of the traffic methods that are working for me now, and how you can use these same techniques to work in your online business also. These strategies are very simple, and once you read them, you will see that it?s very easy to make money online simply and easily.
Here?s the first traffic method that you can use in your online business today:
1) Direct mail to existing customers
Once you develop a large group of customers, there will come a point in time where the traffic from your existing will bring you 80% of your total business profits. Because of this, you will want to do anything that you can to sell more and more of your products to these people - over and over again.
One of the best ways to increase your conversion results and traffic count is with direct mail. You see if you just rely on email marketing to contact your existing customers, you?re missing out on a great bunch of potential profits that you could be getting in your online business. Direct mail has been proven to increase sales of online business owners, and the same can be true of you if you decide to put it into use in your business.
Here?s another way to get traffic to your website:
2) Facebook
Facebook is the number 2 ranked website on the internet (in terms of website traffic), and they are right behind Google (Youtube is number 3 by the way). The more ?likes? and members that you can get to your Facebook page, and the more you interact with them, the more people will start to visit your site repeatedly to learn more free information or even to buy some of your products.
I think all businesses can benefit from Facebook. You can build alot of relationships with your Facebook members, and can create special deals, campaigns, and activities that will allow you to get more website traffic, and boost your sales? all for free. But the first step is getting those Facebook ?likes? and getting people to respond to you.
These 2 ways to get traffic to your website are both very good ways to make your business a success, and to start earning the money that you are looking for in your business. Hopefully you will put them into use.
Good luck with earning the money that you are looking for in your online business.
For more internet marketing secrets, simply visit the website below:
http://www.internetmarketing-rules.com/internetmarketing.html
Source: http://blog.internetmarketing-rules.com/2012/11/direct-mail-and-facebook-for-website.html
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A video from Harvard's Wyss Institute explains how strands of DNA can be assembled into three-dimensional nanostructures like tiny Lego building blocks.
By Alan Boyle
Researchers at Harvard's Wyss Institute have coaxed single strands of DNA to fit together like Lego bricks and form scores of complex three-dimensional shapes, including a teeny-tiny space shuttle. The technique, described in this week's issue of the journal Science, adds a new dimension to molecular construction and should help open the way for nanoscale medical and electronic devices.
"This is a simple, versatile and robust method," the study's senior author, Peng Yin, said in a news release.
The method starts with synthetic strands of DNA that take in just 32 nucleotides, or molecular?bits of genetic code. These individual "bricks" are coded in a way that they fit together like Lego pegs and holes to form larger shapes of a specific design. A cube built up from 1,000 such bricks (10 by 10 by 10) measures just 25 nanometers in width. That's thousands of times smaller than the diameter of a single human hair.
The latest research builds upon work that the Wyss researchers detailed in May, which involved piecing together DNA strands to create two-dimensional tiles (including cute smiley faces). This time around, the strands were twisted in such a way that they could be interlocked, Lego-style. As any visitor to Legoland knows, such structures can get incredibly complex in the hands of a skilled builder.
Yin and his colleagues are still learning their building techniques. Fortunately, the bricks could be programmed to build themselves, with the aid of 3-D modeling software. Once the designs were set, the researchers synthesized strands with the right combinations of nucleotides ??adenosine, thymine, cytosine and guanine ? so that when they were mixed together in a solution, at least some of the bricks would form the desired design.
To demonstrate the method, 102 different 3-D shapes were created using a 1,000-brick template.
The Wyss researchers reported a wide variation in assembly success rate, or yield: Depending on the design, the yield ranged from 1 percent to 40 percent.?That's roughly in the same range as the success rate for another method for molecular assembly, known as DNA origami. The origami method requires more custom work to design the "staples" to hold the DNA structures together, while the Lego-style method can rely more easily on a standard toolbox of DNA bricks.
In the future, DNA origami and DNA brick-building may be used together, said Kurt Gothelf, director of the Center for DNA Nanotechnology at Aarhus University in Denmark. "It is likely that a combination of the two methods will pave the way for making even larger structures in higher yields," Gothelf wrote in a commentary for Science.
Researchers say complex nanostructures could be used as smart drug delivery devices inside the human body, or as the components for microscopic electronic or photonic devices. It may look as if scientists are just playing around with smiley faces and toy shuttles, but a few years from now, DNA bricks will be no laughing matter.
Update for 3:30 p.m. ET: Peng Yin put me in touch with the Wyss Institute's Yonggang Ke, the lead researcher for the study, for an email Q&A. Here's an edited transcript:
Cosmic Log: I'm trying to visualize the self-assembly process. The shapes are designed using software, and that yields a recipe list for different strands that are synthesized, and then the various ingredients are combined to assemble themselves into the desired shapes?
Ke:?"All the designs were done using software. First, a cubic '3-D canvas' model that contains 1,000 'voxels' was generated. [Each voxel represents an 8-base-pair connection between bricks.] Second, a list of a master collection of DNA strands (we ordered 4,455 strands) was generated based on the 3-D canvas. This master collection of strands covers all possibilities of shapes that can be designed from the 1,000-voxel 3-D canvas. Then we made 102 shapes using the software; each shape was designed by removing the unwanted voxels. At last, the software translates each shape to a recipe list of strands and sends the information to a robot for mixing the ingredients."
Q:?Do you have to select 'good' structures of Lego blocks from undesirable or misshapen Lego structures?
A:?"We didn't select the 'good' structures. That is why some structures' yields in the paper are so low. However, there are a few designed structures that failed self-assembly. They were mentioned in the supplementary material."
Q: I mentioned a couple of figures in the May report on your team's work with 2-D shapes: 12 to 17 percent yield, expected production of one desired shape per hour, $7,000 to synthesize a toolkit theoretically capable of producing 2 x 10^93 shapes. Do you have comparable figures for 3-D brick production?
A: "Yields of 3-D DNA-brick shapes were, on average, lower than 2-D DNA-brick shapes, but comparable to 3-D DNA origami structures. We saw yields varied from 1 percent to 40 percent, depending on the designs. The robot can make one 3-D shape per hour, which is similar to the pace for making 2-D shapes.? The master collection of 4,455 strands cost about $11,000, but we can produce 2^1000 (about 10^301) potential shapes. The much larger number of potential shapes is due to the higher resolution in our 3-D brick design." [The size of the voxels is smaller, with just 8 base pairs per voxel.]
Q:?Do you visualize combining the short-strand bricks into a completed structure, or building modular structures that are in turn built up into bigger structures (for example, that nanoscale space shuttle)? I assume this is where the combination of brick-building and origami might come in.
A:?"Combining multiple DNA-brick structures to form a larger structure via 'hierarchical assembly' is certainly on our mind. I think we will inevitably need to combine many different DNA assembly methods, including DNA brick and DNA origami."
Q: It sounds as if you expect bricks as well as origami to be used together for nanostructure synthesis. Is this a change from the way you expected the field to develop in earlier days, or did you always expect that the two approaches would end up being used in combination?
A: "The ultimate goal of the DNA-brick technique and DNA origami is the same: making larger, more complex, more stable DNA structures. The two methods are also intrinsically connected.
"I borrow a paragraph from our paper: 'DNA origami can also be related to the brick framework, in which half of the bricks are concatenated into a long scaffold. ... The successes of constructions that use only short strands (as in bricks) and those that include a long scaffold (as in origami) together suggest a full spectrum of motif possibilities with strands of diverse lengths: Longer strands may provide better structural support, and shorter ones may provide finer modularity and features; the eclectic use of both may lead to the most rapid progression toward greater complexity.'
"We certainly expect the two techniques will complement each other."
Q: Do you feel as if this establishes a sufficient toolkit for nanostructure building, or are there other steps or techniques that will still be required? Are you working on additional techniques?
??A:?"Far from sufficient. The DNA-brick technique is great, compared with a lot of existing methods. It is modular, simple, and can make many complex shapes that were not accessible before. However, it is still not quite enough for many reasons. First of all, the structures are still only nanometer-scale objects. It will be great if we can get them to micrometer or even millimeter sizes. Second, we need to increase the stability of structures for many applications. Third, we want to be able to transfer the structural information to a lot of other materials (e.g. metals, carbon, silicon, protein?) to achieve more functions."
Q: Any more insight into the mechanism that leads to self-assembly?
A: "Right now we don't have any new hypotheses. A more important task for now is to search a reliable assay for studying the assembly mechanism."
Q: Is there any way to put an estimated time frame on applications for DNA structure assembly, or describe the potential applications?
A:?"It is hard to predict a timetable. However, we believe we are really close to making high-profile real-world applications using DNA structures, considering the rapid growth of the field in recent years. Many papers have been published in the last couple of years, showing the potential for DNA structures in biophysical study, plasmonic devices, biosensoring, targeted delivery vehicle, etc.
Q: In May, we mentioned the potential for drug delivery or medical monitoring (for example, by nanomachines in the bloodstream). How does going from 2-D to 3-D change the outlook for applications? What are the big obstacles yet to be overcome?
A:?"For some applications, 2-D DNA structures would suffice. However, for applications like drug delivery, going 3-D makes all the difference. A delivery vehicle/machine has to be a 3-D object that contains protective shell, recognition sites, etc. Note that we are at early stage of developing nano medical devices using DNA structures. The biggest obstacles in the near future are perhaps how to increase the stability of DNA structures in complex biological environments and how to observe the behaviors of the DNA structures in vivo."?
Q: Anything to report on patenting these technologies or forming a venture to commercialize them?
A: "We have filed a provisional patent on the DNA-brick technique. We also have filed patents for other DNA techniques that we have invented in the past. We certainly expect that commercialization of these techniques will be a possibility in the future."
More about DNA assembly:
In addition to Yin and Ke, the authors of the Science paper, "Three-Dimensional Structures Self-Assembled From DNA Bricks," include Luvena L. Ong and William M. Shih. The work was supported by the Office of Naval Research, the Army Research Office, the National Institutes of Health, Wyss Institute and the National Science Foundation.
Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.
Source: http://cosmiclog.nbcnews.com/_news/2012/11/29/15544581-scientists-build-with-dna-bricks?lite
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The Plumrose is Inglenook?s largest cottage home.? Designed by award-winning architect Ross Chapin, the Plumrose possesses all of the character and charm you?ve come to know and love with some added space and flexibility.
This roomy abode features 3-4 bedrooms, 2.5 baths, and a 2.5-car garage.? The open floor plan provides the perfect space for entertaining friends and family!? Like our other homes, the Plumrose accommodates main floor living with a large master bedroom and full bath.? Outside the master bedroom is a private patio and fenced side yard.? The side patio is a great space to relax, enjoy a morning cup of coffee, and read your favorite book.
The second floor houses an additional full bath and more spacious bedrooms!? The bedrooms are bright and airy with cathedral ceilings and enormous walk-in closets.? Another unique feature of the Plumrose is its flexibility in design.? Just take the front upstairs bedroom.? It can be transformed into six different layouts ? a children?s realm with two bedrooms and a playroom or a guest room and office ? to name just two.? The flexibility in design provides you just one more way to customize your cottage home.? Talk to Casey, our builder, to discuss the different possibilities!
View the Plumrose virtual tour >
View photos of the Plumrose >
Inglenook currently has one Plumrose that is available pre-built and move-in ready! ?View our site plan to see where the pre-built Plumrose is located. ?If you?re looking to make a move a few months down the road, a custom-built Plumrose would be a great fit!? The typical build period is 6-8 months depending on weather.
Stop by today to check out the Plumrose and tour our neighborhood.? The Inglenook sales office is open Wednesday-Friday, 2-6PM and Saturday-Sunday, 1-4PM.? To schedule a private tour please contact Dana at 317.844.5584 or via email at inglenookcarmel@gmail.com.
Tags: Cottage style home, Cottage style homes, Homes for sale in Carmel IN, Inglenook, New Homes in Carmel IN, Ross Chapin
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DEAR ABBY: My wife and I have been married for five years. I recently discovered that she made between 10 and 20 porn videos when she was 19. We got married when she was 27. We have four kids from two previous marriages.I am devastated. When I confronted her about it, she cried harder than I had ever seen. She said she was lost, and it's the biggest regret of her entire life.I understand how hard it can be to tell someone you have done something like this. I haven't led a perfect life either, and I have my own skeletons and things that I would never mention. But still, I can't get over this. ...
Source: http://news.yahoo.com/bullish-goldman-sachs-report-sends-rim-skyward-154023842.html
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LIEUTENANT Colonel Ben Wrench, Commanding Officer of 1 Scots, yesterday spoke candidly of the ?insider threat?, or ?green on blue? menace, in Helmand province.
He said: ?On 11 November, with Captain Walter Barrie, we had a major setback through the insider threat.
?I?m sure many people cannot understand how the very people we have come to help might turn their rifles on us, and it?s hard for us to come to terms with it.
?But the fact is that there are people out there who don?t want us to be here and we have to understand that and we have to endeavour to give ourselves the best protection.
?We look inwards and we look to find the insurgent within, and I have to say there are not that many.
?If there is a view that the ANA [Afghan National Army] is riddled with insurgents, we don?t have any evidence of that.?
He stressed such incidents might not always be connected to the insurgency, listing drug use and battle fatigue as alternative causes.
He also claimed that the Afghan troops being trained at Camp Shorobak, next door to ?1 Scots? Camp Tombstone, were just as wary of the insider threat as the British troops. ?The reality is that such people would just as readily kill an Afghan soldier as an ISAF [International Security Assistance Force] soldier,? he added.
Col Wrench said Cpt Barrie?s death had been a devastating blow for ANA soldiers. He said: ?They were in shock but they have been doing everything they can to support the investigation.?
2014 target
BRITISH front-line combat troops will be out of Afghanistan by the end of 2014 under the UK government?s plans to withdraw from the war zone.
Yesterday Prime Minister David Cameron chaired a meeting of the National Security Council to discuss the detailed timetable for withdrawing UK forces over the next two years.
It is understood that the plan is to keep the number of forces stable at 9,000 until September next year, and then withdraw 8,000 over the next 12 months, though details were not published.
A final 1,000 troops will
be expected to remain for training and logistical purposes.
Source: http://www.scotsman.com/afghanistan-troops-there-are-many-who-do-not-want-us-here-1-2663403
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President Barack Obama gestures as he speaks in the Eisenhower Executive Office Building, on the White House campus in Washington, Wednesday, Nov. 28, 2012, about how middle class Americans would see their taxes go up if Congress fails to act to extend the middle class tax cuts. The president said he believes that members of both parties can reach a framework on a debt-cutting deal before Christmas. (AP Photo/Susan Walsh)
President Barack Obama gestures as he speaks in the Eisenhower Executive Office Building, on the White House campus in Washington, Wednesday, Nov. 28, 2012, about how middle class Americans would see their taxes go up if Congress fails to act to extend the middle class tax cuts. The president said he believes that members of both parties can reach a framework on a debt-cutting deal before Christmas. (AP Photo/Susan Walsh)
With the presidential seal on the wall in the background, President Barack Obama pauses in the Eisenhower Executive Office Building, on the White House campus in Washington, Wednesday, Nov. 28, 2012, where he spoke about how middle class Americans would see their taxes go up if Congress fails to act to extend the middle class tax cuts. The president said he believes that members of both parties can reach a framework on a debt-cutting deal before Christmas. (AP Photo/Pablo Martinez Monsivais)
House Speaker John Boehner of Ohio speaks during a news conference on Capitol Hill in Washington, Wednesday, Nov. 28, 2012, following a closed strategy session. (AP Photo/J. Scott Applewhite)
Former White House Chief of Staff Erskine Bowles, co-chair of the National Commission on Fiscal Responsibility and Reform, is pursued by reporters on Capitol Hill in Washington, Wednesday, Nov. 28, 2012, following a closed-door meeting House Speaker John Boehner of Ohio. (AP Photo/J. Scott Applewhite)
Senate Majority Leader Harry Reid of Nev. pauses as he meet with reporters on Capitol in Washington, Tuesday, Nov. 27, 2012, following a Democratic strategy session. (AP Photo/J. Scott Applewhite)
WASHINGTON (AP) ? The White House and a key congressional Democrat hinted at fresh concessions on taxes and cuts to Medicare and other government benefit programs Wednesday as bargaining with Republicans lurched ahead to avoid the year-end "fiscal cliff" that threatens to send the economy into a tailspin.
Increasing numbers of rank-and-file Republicans also said they were ready to give ground, a boost for House Speaker John Boehner and other party leaders who say they will agree to higher tax revenues as part of a deal if it also curbs benefit programs as a way to rein in federal deficits.
"I'll go anywhere and I'll do whatever it takes to get this done," President Barack Obama said as he sought to build pressure on Republicans to accept his terms ? a swift renewal of expiring tax cuts for all but the highest income earners. "It's too important for Washington to screw this up," he declared.
For all the talk, there was no sign of tangible progress on an issue that marks a first test for divided government since elections that assured Obama a second term in the White House while renewing Republican control in the House.
"It's time for the president and Democrats to get serious about the spending problem that our country has," Boehner said at a news conference in the Capitol. He, like Obama, expressed optimism that a deal could be reached.
At the same time, he publicly disagreed with one GOP lawmaker, Rep. Tom Cole of Oklahoma, who said he was ready to go along with Obama's plan to renew most but not all of the expiring income tax cuts. "It'll hurt the economy" to raise rates for anyone, said Boehner.
Separately, at a closed-door meeting with the rank and file, the speaker told fellow Republicans they are on solid political ground in refusing to let tax rates rise. He circulated polling data showing the public favors closing loopholes to raise revenue far more than it supports raising rates on incomes over $250,000.
There were no face-to-face talks between the administration and lawmakers during the day, although the White House is dispatching Treasury Secretary Tim Geithner and top legislative aide Rob Nabors to a series of sessions with congressional leaders on Thursday.
On Wednesday, a group of corporate CEOs pushing for a deal met separately with top Democratic and Republican leaders in the House, joined by Erskine Bowles, who was co-chairman of a deficit commission Obama appointed earlier in his term.
Speaking to reporters before a session with business leaders, House Democratic leader Nancy Pelosi of California said the bargaining ought to begin where deficit talks between Obama and Boehner broke down 18 months ago "and go from there to reach an agreement."
She didn't say so, but at the time, the two men were exchanging offers that called for at least $250 billion in cuts from Medicare over a decade, and another $100 billion from Medicaid and other federal health programs. Among the changes under discussion ? with Obama's approval ? was a gradual increase in the eligibility age for Medicare from 65 to 67, as well as higher fees for beneficiaries.
Also on the table at the time was a plan to curtail future cost-of-living increases for Social Security and other benefit programs.
Those negotiations faltered in a hail of recriminations after the president upped his demand for additional tax revenue and conservatives balked. At the same time liberals were objecting to savings from Medicare and Social Security.
Now, more than a year and one election later, Obama has said repeatedly he is open to alternatives to his current proposal to raise additional tax revenue. But he also says he will refuse to sign legislation that extends the current top rates on incomes over $200,000 for individuals and $250,000 for couples.
Instead, he is pushing Congress to renew expiring tax cuts for all income below those levels as an interim measure ? an offer Boehner and Republicans generally say is unacceptable because it would mean higher taxes on small business owners.
Bowles said during the day that Obama might be willing to back off his demand that the top rate revert all the way from 35 percent to 39.6 percent, where it was a decade ago before tax cuts sought by then-President George W. Bush took effect.
At the White House, spokesman Jay Carney sidestepped questions. "If I told you how much flexibility the president had, it would eliminate his flexibility," he said.
He noted that Obama has said he will listen to alternatives, but the spokesman said, "The most basic, simplest, most efficient way to achieve that revenue target is by returning the rates for top earners back to those that were in place in the Clinton era," when the top rate on personal income was the 39.6 percent.
The goal of the talks is to produce a long-term deficit-cutting deal that will allow the cancellation of tax increases and spending cuts scheduled for the end of the year that numerous economists say threaten a new recession.
While the obstacles are numerous, there are other political imperatives pushing the two sides toward an agreement.
Unemployment benefits expire for some of the long-term jobless at the end of the year. Additionally the government is expected to need an increase in borrowing authority early next year or face the possibility of a default. Any agreement on that is expected to raise the current $16.4 trillion level.
___
Associated Press writers Andrew Taylor and Jim Kuhnhenn contributed to this story.
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UN Ambassador Susan Rice leaves a meeting on Capitol Hill in Washington, Wednesday, Nov. 28, 2012, with Sen. Susan Collins, R- Maine, and Sen. Bob Corker, R-Tenn., about the Benghazi terrorist attack. Rice continued her fight Wednesday to win over skeptics in the Senate who could block her chances at becoming the next U.S. secretary of state. Republican lawmakers said they were even more troubled after face-to-face meetings with her over the handling of the Sept. 11 deadly attack on the U.S. Consulate in Benghazi, Libya. (AP Photo/ Evan Vucci)
UN Ambassador Susan Rice leaves a meeting on Capitol Hill in Washington, Wednesday, Nov. 28, 2012, with Sen. Susan Collins, R- Maine, and Sen. Bob Corker, R-Tenn., about the Benghazi terrorist attack. Rice continued her fight Wednesday to win over skeptics in the Senate who could block her chances at becoming the next U.S. secretary of state. Republican lawmakers said they were even more troubled after face-to-face meetings with her over the handling of the Sept. 11 deadly attack on the U.S. Consulate in Benghazi, Libya. (AP Photo/ Evan Vucci)
Sen. Susan Collins, R-Maine, ranking Republican on the Senate Homeland Security and Governmental Affairs Committee walks to a meeting on Capitol Hill in Washington, Wednesday, Nov. 28, 2012, for a meeting with UN Ambassador Susan Rice. Rice continued her fight Wednesday to win over skeptics in the Senate who could block her chances at becoming the next U.S. secretary of state, while Republican lawmakers said they were even more troubled after face-to-face meetings with her over the handling of the Sept. 11 deadly attack on the U.S. Consulate in Benghazi, Libya. (AP Photo/ Evan Vucci)
UN Ambassador Susan Rice arrives for a meeting on Capitol Hill in Washington Wednesday, Nov. 28, 2012, with Sen. Susan Collins, R- Maine and Sen. Corker, R-Tenn., to discuss the Benghazi terrorist attack. Rice continued her fight Wednesday to win over skeptics in the Senate who could block her chances at becoming the next U.S. secretary of state, while Republican lawmakers said they were even more troubled after face-to-face meetings with her over the handling of the Sept. 11 deadly attack on the U.S. Consulate in Benghazi, Libya. (AP Photo/ Evan Vucci)
UN Ambassador Susan Rice leaves a meeting on Capitol Hill in Washington, Wednesday, Nov. 28, 2012, with Sen. Susan Collins, R- Maine, and Sen. Bob Corker, R-Tenn., about the Benghazi terrorist attack. Rice continued her fight Wednesday to win over skeptics in the Senate who could block her chances at becoming the next U.S. secretary of state. Republican lawmakers said they were even more troubled after face-to-face meetings with her over the handling of the Sept. 11 deadly attack on the U.S. Consulate in Benghazi, Libya. (AP Photo/ Evan Vucci)
WASHINGTON (AP) ? A moderate Republican senator, vital to any White House hopes of getting U.N. Ambassador Susan Rice confirmed as secretary of state, said Wednesday she couldn't back any nomination until more questions are answered about the deadly Sept. 11 attack in Libya and Rice's State Department role during the 1998 U.S. Embassy bombing in Kenya.
In a fresh suggestion of eroding GOP support for Rice, Sen. Susan Collins of Maine emerged from a 90-minute, closed-door meeting with the ambassador voicing new criticism of her initial account about Libya. Collins also questioned what Rice, the assistant secretary of state for African Affairs in the Clinton administration, knew about requests for enhanced embassy security before the Nairobi truck bombing.
Pressed on how she would vote if President Barack Obama names Rice to succeed Secretary of State Hillary Rodham Clinton, Collins said, "I would need to have additional information before I could support her nomination."
President Barack Obama came to Rice's defense during a Cabinet meeting, calling her "extraordinary" and saying he couldn't be prouder of the job she has done as U.N. ambassador. Cabinet members joined Obama in applauding Rice, who attended the meeting. Obama has not named a replacement for Clinton, who has said she intends to step down soon.
At the State Department, Clinton was asked about her possible replacement.
"Susan Rice has done a great job as our ambassador to the United Nations," Clinton said. "Of course, this decision about my successor is up to the president, but I am very happy he has the opportunity with a second term to make a decision."
The misgivings from Collins, the top Republican on the Homeland Security Committee, came one day after three other GOP senators said they would try to block Rice's nomination. Sens. John McCain of Arizona, Lindsey Graham of South Carolina and Kelly Ayotte of New Hampshire said they were more troubled than ever by Rice's answers on Libya even though the ambassador conceded that her much-maligned first explanation was wrong.
In an unusual move, Rice and acting CIA Director Michael Morell have held two days of private meetings with Republican senators in hopes of assuaging their concerns. Privately, Senate Republicans said they had hoped the conversations would quiet the criticism as they want to avoid the spectacle of a postelection challenge to a female African-American nominee.
Instead, the sessions have cast further doubt on her chances for the top State Department job and increased the likelihood of a protracted fight if Obama does choose her. Although Democrats will have 55 votes in the next Congress, the president would need the support of five Republicans to avoid a filibuster of the nomination. Collins would be a prime candidate to help avoid a filibuster of the nomination.
Collins said she was troubled by Rice's "political role" in downplaying the Libya attack as a spontaneous demonstration over an anti-Muslim video rather than a terrorist attack by al-Qaida affiliates in a series of Sunday talk show appearances on Sept. 16 ? five days after the attack and weeks before the election.
U.S. Ambassador Chris Stevens and three other Americans were killed in the raid on the U.S. diplomatic mission.
Rice has said she was relying on talking points provided by U.S. intelligence.
Introducing another issue certain to be fodder for any confirmation battle, Collins said she pressed Rice about security at the U.S. Embassy in Nairobi in 1998 when a truck bomb was set off outside the facility, killing more than 200 Kenyans and 12 Americans.
"What troubles me so much is the Benghazi attack in many ways echoes the attacks on those embassies in 1998 when Susan Rice was head of the African region for our State Department," Collins told reporters after the meeting. "In both cases, the ambassador begged for additional security."
Collins said Rice told her she was not involved directly in turning down the request for improved security. The Maine senator said that in light of Rice's position, she had to be aware of the general threats and U.S. Ambassador Prudence Bushnell's requests for security upgrades in Kenya.
Review boards headed by former Joint Chiefs of Staff chairman Adm. William J. Crowe after the Aug. 7, 1998, bombings of the U.S. embassies in Kenya and Tanzania did not find reasonable cause that any U.S. employee breached his duty in connecting with the bombings. Rice was not blamed.
However, Crowe said the boards believed there was a "collective failure" by several administrations and Congress over a decade to invest adequately to shore up vulnerable U.S. diplomatic missions around the world.
Rice has emerged as the front-runner for the top job at State, though Senate Foreign Relations Committee Chairman John Kerry, D-Mass., passed over for the job in 2008, is considered a strong alternative.
In a clear message to the White House, Collins said Kerry would have no problem winning Senate confirmation.
"I think John Kerry be an excellent appointment and would be easily confirmed by his colleagues," Collins said.
Sen. Bob Corker of Tennessee, who is in line to become the top Republican on the Foreign Relations Committee, was more circumspect about Rice's chances after his own meeting with the ambassador.
The GOP senator suggested that Obama "take a deep breath and nominate the person he really believes is the very best person for secretary of state, regardless of relationships."
Corker, who traveled to Libya in early October, was highly critical of the administration and the intelligence community, saying that "the whole issue of Benghazi has been a tawdry affair."
Democrats have rallied to defend Rice, casting the Republican criticism as political scapegoating.
"You know it's a shame to create a sideshow that seems, I think, very clearly to be very political out of something that really has no bearing on what happened in Benghazi," White House spokesman Jay Carney said Wednesday.
Rep. Adam Schiff, D-Calif., a member of the House Intelligence Committee, called the criticism a "transparent attempt" to deny Obama a potential Cabinet choice.
The issue remained at the forefront as the Senate, in debating a defense policy bill, approved an amendment by McCain that would lead to an increase of up to 1,000 Marine Corps personnel to provide security at U.S. diplomatic missions around the world.
___
Associated Press writer Matthew Lee contributed to this report.
___
Donna Cassata can be followed on Twitter at http://twitter.com/DonnaCassataAP
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Regions of activated BAT (brown adipose tissue) outlined in green in fused 18F-FDG- PET/CT image (coronal view). Photos courtesy of Megan Ruth
It?s as counterintuitive as counterintuition can be: could the breakthrough fix for fatness be found in?fat?
It turns out that all fat is not created equal. Brown fat, named for its color and found in small amounts in strange places like our backs and necks, burns calories instead of warehousing them. Until three years ago, no one even knew adults had brown fat. Researchers had found it in rodents and human babies, both of whom cannot shiver (which burns calories) and therefore need brown fat as a heat-maker to stay warm. Then they studied scans of adults in cold rooms and voil??grownups had brown fat, too.
So the purpose of brown fat is to help people to stay warm when it?s cold. But this calorie incinerator could be a potential weight-shedding wonder, too. Boston Medical Center?s Caroline Apovian and Megan Ruth find the potential so promising that Ruth and another colleague have pored over 1,100 PET scans?done at BMC between 2006 and 2009?to find appropriate subjects for research into brown fat.
Apovian?a School of Medicine professor and head of the BMC Nutrition and Weight Management Center?and Ruth, a BMC postdoctoral associate, are part of a team that devised a software program to quantify the amount of brown fat in the people who were scanned. They narrowed the field to 35 scans.
?What we?d like to do is figure out a way to activate that brown fat and have the white fat around it??the ordinary kind??make more brown fat,? says Apovian. She is hopeful that if they can trick the body into producing more brown fat, ?people won?t have to exercise, which nobody seems to want to do.?
Comparison of 18F-FDG-PET/CT image (top) with algorithm-generated image (bottom) exemplifying BAT in supraclavicular region (coronal view). BAT appears bright white/yellow in 18F-FDG-PET/CT and green in computer-generated image (white=bone).
The work done by Apovian and her team complements research at the Dana-Farber Cancer Institute, where researchers engineered brown fat production in mice. They?re ?doing work in animals. We do human research,? Apovian says.
The first step in cracking the riddle of how to make brown fat is pinpointing and measuring how much you have to begin with. Enter the computer program, which allows the researchers to measure brown fat in the scans without the aid of a radiologist.
The BU researchers are seeking funding for their next step, which will test their software program on actual subjects rather than scans. For the subjects, it will be, quite literally, chilling work: the researchers will make them cold?they may stand on an ice block or don a bomb deactivation suit filled with cold water?allowing the program to measure brown fat before and after the onset of cold. ?The more obese you are, the less brown fat you have,? says Apovian. ?The more brown fat you have, the more calories you can burn.?It seems that there?s more brown fat in lean people, and so our hypothesis is that that?s why they?re lean. But we don?t know that.? She says it could be six months before they have the money in hand to proceed.
It?s too soon for us to cancel our gym memberships, though. ?In the next 10 years, we?re not curing the obesity epidemic,? Apovian says. ?We don?t know enough about brown fat. We may find that we can?t activate it. We may find that we can activate it, but it doesn?t contribute that much, because there?s not a lot of it. We may find that it causes cancer. This is just at the very beginning stages. Maybe in 50 years, we?ll have found a way to turn white fat into brown fat so that you can eat whatever you want, eat junk food, and still stay lean. But not now.?
The project?s other researchers are Thomas Szabo, a College of Engineering research professor, Gustavo Mercier, a MED assistant professor, and Tyler Wellman, an PhD candidate in the Department of Biomedical Engineering.
Next, in part four of our series, ?Exploring the Causes of Black Women?s Obesity.? Read part one, ?Deciphering the Body?s Healthy Message.? Read part two, ?Solving the Childhood Obesity Puzzle, One Piece at a Time.?
Source: http://www.bu.edu/today/2012/the-cure-for-obesity-fat/
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